Dr. Theirry Hertoghe On Hormone Therapy And Longevity

• 00:10 Introduction to the Podcast

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  • Dr. Thierry Hertoghe, an expert in hormone optimization, discusses the significance of hormones, particularly testosterone, growth hormone, thyroid, and other lesser-known hormones in influencing how we look, feel, and perform as we age.

• 03:41 The Role of Hormone Optimization in Healthy Aging

  • Dr. Hertoghe emphasizes the importance of hormone optimization and how age plays a role in determining when one should consider hormone replacement therapy. He discusses the visible signs and symptoms of hormone deficiencies.

• 08:04 Facial Features and Hormone Deficiencies

  • Dr. Hertoghe provides examples of facial features that indicate hormone deficiencies, such as a receding hairline, pale complexion, deep wrinkles on the forehead, and eyebrow thinning, highlighting the importance of identifying these visual clues.

• 13:41 Addressing Concerns About Hormone Replacement Therapy

  • Dr. Hertoghe addresses concerns related to hormone replacement therapy, such as its impact on cancer growth. He explains the benefits of hormone therapy and how it positively affects overall health.

• 15:49 Dosage and Assessment of Hormone Replacement Therapy

  • Dr. Hertoghe discusses the importance of a comprehensive assessment, combining lab tests, physical examinations, and patient questionnaires to determine the right hormone replacement therapy dosage. He emphasizes individualized treatment.

• 19:29 Gene Therapy and Its Potential

  • Dr. Hertoghe touches on gene therapy as a developing field and its potential, particularly in relation to telomeres and how it may contribute to extending healthy aging.

• 21:36 Hormone Replacement Therapy and Dosing Frequency

  • Hormone replacement therapy often requires daily dosing.
  • Daily dosing can spare the glands and have long-term benefits.
  • Overdosing is not recommended; individualized dosing is more effective.

• 24:52 Nighttime Administration of Growth Hormone

  • Growth hormone is best taken in the evening (98% of patients).
  • Nighttime administration mimics the natural growth hormone secretion pattern.
  • Morning administration may lead to decreased energy due to cortisol reduction.

• 25:06 IGF-1 Supplementation for Growth Hormone

  • IGF-1 supplementation is recommended for most patients above age 50.
  • Combining IGF-1 and growth hormone in treatment appears to work well.
  • Long-acting IGF-1 options are available, but human studies are limited.

• 29:25 Hormonal Regulation of Cholesterol and Health

  • Hormone deficiencies can lead to increased cholesterol levels.
  • Correcting hormone deficiencies can help lower cholesterol naturally.
  • Coffee and alcohol consumption can elevate estrogen levels in men.

• 35:06 Desiccated Thyroid vs. T3 or T4 for Thyroid Hormone Replacement

  • Desiccated thyroid contains a spectrum of thyroid hormones, including T3 and T4.
  • Desiccated thyroid can provide more natural and stable thyroid hormone replacement.
  • Classical thyroxine (T4) alone may not be as effective in some cases.

• 38:29 Estrogen and Estrogen Blockers for Men

  • Men should be cautious about high estrogen levels, which can lead to various issues.
  • Blocking estrogen conversion may be necessary in some cases.
  • High estrogen in men can result from factors like coffee and alcohol consumption.

• 41:51 Capillary Health and the Importance of Dilation

  • Capillaries' ability to dilate is essential for overall health and function.
  • Warm and cold temperature alternation can help open capillaries and improve circulation.
  • Various hormones, including thyroid and estrogen, play roles in capillary health.

• 43:38 Injecting hormones for local benefits

  • Injecting growth hormone around the eyes can have local benefits, rejuvenating the face and improving eyesight.
  • Mesotherapy with small injections around the eyes and face can lead to skin rejuvenation.
  • The treatment's effectiveness can vary based on the patient's overall health and nutrition.

• 45:43 Possible effects on coronary calcium and arterial aging

  • Vitamin K supplementation may have positive effects on calcium deposits in coronary arteries.
  • Arterial calcification might not necessarily be a bad thing, as it could be a protective response.
  • Some treatments can reverse arterial aging (atherosclerosis), but reversing coronary calcium is more challenging.

• 47:04 The role of vasopressin and its effects

  • Vasopressin can enhance memory when taken in the morning.
  • Vasopressin helps retain water in the body, improving skin quality and reducing the need for frequent urination.
  • It can be beneficial for individuals who experience sleep disruptions due to frequent bathroom visits.

• 50:23 Testosterone replacement therapy and the importance of age

  • Consideration of testosterone replacement therapy after the age of 30, particularly for those who engage in intensive sports.
  • The importance of maintaining a balance between hormones.
  • The significance of adjusting testosterone doses based on individual body size and muscle mass.

• 56:01 Administration and optimization of testosterone

  • The preference for transdermal creams, especially in younger patients.
  • Recommendations for applying testosterone cream to specific areas, such as the face.
  • Frequency and methods of administering testosterone injections for older individuals and athletes.

• 59:31 Balancing anabolic hormones and considering rapamycin

  • Discussion of rapamycin's potential benefits in small doses and potential issues with high doses.
  • The importance of maintaining a balanced hormone profile for overall health.
  • How excessive use of anabolic hormones, like testosterone, can lead to imbalances and health issues.

• 01:04:42 The significance of cortisol in health and well-being

  • The role of cortisol in providing energy, stamina, and resistance to stress.
  • The potential consequences of cortisol deficiency and adrenal burnout.
  • The need for careful consideration when supplementing with cortisol due to its influence on multiple other hormones.

• 01:05:58 Hormone Replacement Therapy and Its Importance

  • Dr. Hertoghe discusses various hormones, including DHA, cortisol, aldosterone, and their significance.
  • Low cortisol can lead to a range of issues, including negative thinking and paranoia.
  • Other hormones like melatonin, 5-HTP, and GABA play a role in improving sleep quality.

• 01:09:27 Dosage and Specifics of Cortisol Replacement

  • Dr. Hertoghe talks about the dosage of cortisol replacement therapy.
  • The absorption rate of natural cortisol and the need for higher doses in some cases.
  • Adjusting cortisol dosage for specific situations, like running a marathon.

• 01:10:52 Additional Resources and Information on Hormone Replacement

  • Dr. Hertoghe mentions his website and clinic for more information and treatment options.
  • He highlights his book on testosterone therapy, offering comprehensive guidance on hormone replacement.
  • Emphasizes the importance of taking control of your health and happiness through proper hormone management.

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